Pesquisa | BVS IEC

1.

Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling.

Kim, Sangjin; Beltran, Bruno; Irnov, Irnov; Jacobs-Wagner, Christine.

Cell ; 179(1): 106-119.e16, 2019 Sep 19.

Artigo em Inglês | MEDLINE | ID: mdl-31539491

2.

Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis.

Eckartt, Kathryn A; Delbeau, Madeleine; Munsamy-Govender, Vanisha; DeJesus, Michael A; Azadian, Zachary A; Reddy, Abhijna K; Chandanani, Joshua; Poulton, Nicholas C; Quiñones-Garcia, Stefany; Bosch, Barbara; Landick, Robert; Campbell, Elizabeth A; Rock, Jeremy M.

Nature ; 628(8006): 186-194, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38509362

3.

Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance.

Hurst-Hess, Kelley R; Saxena, Aavrati; Rudra, Paulami; Yang, Yong; Ghosh, Pallavi.

Mol Cell ; 82(17): 3166-3177.e5, 2022 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-35905736

4.

HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics.

Surette, Matthew D; Waglechner, Nicholas; Koteva, Kalinka; Wright, Gerard D.

Mol Cell ; 82(17): 3151-3165.e9, 2022 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-35907401

5.

High-resolution landscape of an antibiotic binding site.

Yang, Kevin B; Cameranesi, Maria; Gowder, Manjunath; Martinez, Criseyda; Shamovsky, Yosef; Epshtein, Vitaliy; Hao, Zhitai; Nguyen, Thao; Nirenstein, Eric; Shamovsky, Ilya; Rasouly, Aviram; Nudler, Evgeny.

Nature ; 622(7981): 180-187, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37648864

6.

Substrate geometry affects population dynamics in a bacterial biofilm.

Postek, Witold; Staskiewicz, Klaudia; Lilja, Elin; Waclaw, Bartlomiej.

Proc Natl Acad Sci U S A ; 121(17): e2315361121, 2024 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-38621130

7.

A protective role for type I interferon signaling following infection with Mycobacterium tuberculosis carrying the rifampicin drug resistance-conferring RpoB mutation H445Y.

Bobba, Suhas; Chauhan, Kuldeep S; Akter, Sadia; Das, Shibali; Mittal, Ekansh; Mathema, Barun; Philips, Jennifer A; Khader, Shabaana A.

PLoS Pathog ; 20(4): e1012137, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38603763

8.

Trained immunity in recurrent Staphylococcus aureus infection promotes bacterial persistence.

Lin, Xiao-Qi; Liu, Zhen-Zhen; Zhou, Cheng-Kai; Zhang, Liang; Gao, Yu; Luo, Xue-Yue; Zhang, Jian-Gang; Chen, Wei; Yang, Yong-Jun.

PLoS Pathog ; 20(1): e1011918, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38241414

9.

Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.

Mosaei, Hamed; Molodtsov, Vadim; Kepplinger, Bernhard; Harbottle, John; Moon, Christopher William; Jeeves, Rose Elizabeth; Ceccaroni, Lucia; Shin, Yeonoh; Morton-Laing, Stephanie; Marrs, Emma Claire Louise; Wills, Corinne; Clegg, William; Yuzenkova, Yulia; Perry, John David; Bacon, Joanna; Errington, Jeff; Allenby, Nicholas Edward Ellis; Hall, Michael John; Murakami, Katsuhiko S; Zenkin, Nikolay.

Mol Cell ; 72(2): 263-274.e5, 2018 10 18.

Artigo em Inglês | MEDLINE | ID: mdl-30244835

10.

Antibiotic perseverance increases the risk of resistance development.

Brandis, Gerrit; Larsson, Jimmy; Elf, Johan.

Proc Natl Acad Sci U S A ; 120(2): e2216216120, 2023 01 10.

Artigo em Inglês | MEDLINE | ID: mdl-36595701

11.

The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance.

Lake, M Alexandra; Adams, Kristin N; Nie, Feilin; Fowler, Elaine; Verma, Amit K; Dei, Silvia; Teodori, Elisabetta; Sherman, David R; Edelstein, Paul H; Spring, David R; Troll, Mark; Ramakrishnan, Lalita.

Proc Natl Acad Sci U S A ; 120(7): e2215512120, 2023 02 14.

Artigo em Inglês | MEDLINE | ID: mdl-36763530

12.

A 24-Week, All-Oral Regimen for Rifampin-Resistant Tuberculosis.

Nyang'wa, Bern-Thomas; Berry, Catherine; Kazounis, Emil; Motta, Ilaria; Parpieva, Nargiza; Tigay, Zinaida; Solodovnikova, Varvara; Liverko, Irina; Moodliar, Ronelle; Dodd, Matthew; Ngubane, Nosipho; Rassool, Mohammed; McHugh, Timothy D; Spigelman, Melvin; Moore, David A J; Ritmeijer, Koert; du Cros, Philipp; Fielding, Katherine.

N Engl J Med ; 387(25): 2331-2343, 2022 12 22.

Artigo em Inglês | MEDLINE | ID: mdl-36546625

13.

Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.

Lin, Wei; Mandal, Soma; Degen, David; Liu, Yu; Ebright, Yon W; Li, Shengjian; Feng, Yu; Zhang, Yu; Mandal, Sukhendu; Jiang, Yi; Liu, Shuang; Gigliotti, Matthew; Talaue, Meliza; Connell, Nancy; Das, Kalyan; Arnold, Eddy; Ebright, Richard H.

Mol Cell ; 66(2): 169-179.e8, 2017 Apr 20.

Artigo em Inglês | MEDLINE | ID: mdl-28392175

14.

Pharmacokinetics and cardiac safety of clofazimine in children with rifampicin-resistant tuberculosis.

Ali, Ali Mohamed; P Solans, Belén; Hesseling, Anneke C; Winckler, Jana; Schaaf, H Simon; Draper, Heather R; van der Laan, Louvina; Hughes, Jennifer; Fourie, Barend; Nielsen, James; Wiesner, Lubbe; Garcia-Prats, Anthony J; Savic, Radojka M.

Antimicrob Agents Chemother ; 68(1): e0079423, 2024 Jan 10.

Artigo em Inglês | MEDLINE | ID: mdl-38112526

15.

Clofazimine as a substitute for rifampicin improves efficacy of Mycobacterium avium pulmonary disease treatment in the hollow-fiber model.

Salillas, Sandra; Raaijmakers, Jelmer; Aarnoutse, Rob E; Svensson, Elin M; Asouit, Khalid; van den Hombergh, Erik; Te Brake, Lindsey; Stemkens, Ralf; Wertheim, Heiman F L; Hoefsloot, Wouter; van Ingen, Jakko.

Antimicrob Agents Chemother ; 68(3): e0115723, 2024 Mar 06.

Artigo em Inglês | MEDLINE | ID: mdl-38259101

16.

Targeted sequencing from cerebrospinal fluid for rapid identification of drug-resistant tuberculous meningitis.

Tram, Trinh Thi Bich; Trieu, Le Pham Tien; Nhat, Le Thanh Hoang; Thu, Do Dang Anh; Quang, Nguyen Le; Bang, Nguyen Duc; Chau, Tran Thi Hong; Thwaites, Guy E; Walker, Timothy M; Ha, Vu Thi Ngoc; Thuong, Nguyen Thuy Thuong.

J Clin Microbiol ; 62(4): e0128723, 2024 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-38466092

17.

Environmentally Friendly Degradation and Detoxification of Rifampicin by a Bacterial Laccase and Hydrogen Peroxide.

Durão, Paulo; Kis, Peter; Chelo, Ivo M; Ventura, M Rita; Martins, Lígia O.

Chembiochem ; 25(2): e202300627, 2024 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-37947295

18.

Assessing Pleiotropic Effects of a Mixed-Mode Perpetrator Drug, Rifampicin, by Multiple Endogenous Biomarkers in Dogs.

Liu, Renmeng; Ma, Bin; Mok, Marilyn M; Murray, Bernard P; Subramanian, Raju; Lai, Yurong.

Drug Metab Dispos ; 52(3): 236-241, 2024 Feb 14.

Artigo em Inglês | MEDLINE | ID: mdl-38123963

19.

How has the municipal availability of the GeneXpert®MTB/RIF system affected the detection of drug-resistant tuberculosis in Brazil?

Aguilar-Jiménez, Jhancy Rocío; Pelissari, Daniele Maria; Diaz-Quijano, Fredi Alexander.

Trop Med Int Health ; 29(1): 57-62, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-37919228

20.

A reconstructed genome-scale metabolic model of Helicobacter pylori for predicting putative drug targets in clarithromycin and rifampicin resistance conditions.

Mofidifar, Sepideh; Yadegar, Abbas; Karimi-Jafari, Mohammad Hossein.

Helicobacter ; 29(2): e13074, 2024.

Artigo em Inglês | MEDLINE | ID: mdl-38615332

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Instituto Evandro Chagas

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